?덈뀞?섏꽭??
?ㅻ뒛?� 鍮꾩븘洹몃씪???쒕꽕由?쑝濡??먮━ ?뚮젮吏?移대쭏洹몃씪, 移대쭏洹몃씪 ?ㅼ쓽 遺�?묒슜怨?蹂듭슜踰뺤뿉 ?�???덈궡???쒕━寃좎뒿?덈떎.
?꾨옒 ?댁슜?� 怨듭떇 ?섏빟???뺣낫瑜?諛뷀깢?쇰줈 ?뺣━?덉뒿?덈떎. 媛쒖씤 嫄닿컯 ?곹깭???곕씪 蹂듭슜踰빧룸??묒슜?� ?щ씪吏????덉쑝?? 諛섎뱶???섏궗쨌?쎌궗?� ?곷떞?섏꽭??
諛쒓린遺�??移섎즺?쒕뒗 ?�遺�遺??꾨Ц?섏빟?덉쑝濡?遺꾨쪟?섏뼱 泥섎갑?꾩씠 ?꾩슂?⑸땲?? 媛쒖씤?ъ슜 紐⑹쟻 ?댁쇅吏곴뎄媛� 媛�?ν븳 寃쎌슦???덉쑝?? ?뺥뭹 ?뺤씤怨??덉쟾??蹂듭슜??臾댁뾿蹂대떎 以묒슂?⑸땲??
移대쭏洹몃씪怨⑤뱶(移대쭏洹몃씪 100mg) 怨?移대쭏洹몃씪 ???쒖꽌濡??댄렣蹂댁떆寃좎뒿?덈떎.
- 移대쭏洹몃씪 怨⑤뱶(移대쭏洹몃씪100mg)
遺�?묒슜
-鍮덈룄蹂?二쇱슂 遺�?묒슜 諛??꾩긽 寃�?ъ튂 ?댁긽
<1 % ?댁긽>
?덇? ?뺤옣 (?띿“, ?띿“), ?먰넻
<0.1 ~ 1 % 誘몃쭔>
媛�?댄넻利? 媛�?대몢洹쇨굅由? 留λ컯??鍮⑤씪吏? ?꾧린利? 議몃┝, ?쇰?, AST (GOT) 利앷?, 援ъ뿭吏? ?꾩옣 ?μ븷, 援ш컝, ?뚰솕 遺덈웾, 蹂듯넻, 鍮꾩뿼, 愿�?덊넻, 洹쇱쑁?? 諛쒖쭊, ??異⑺삁, 寃곕쭑?? 愿묒떆利? ?쒓컖 ?μ븷, CK (CPK) 利앷?, ?듭쬆, 紐몄쓽 ?닿린
<0.1 %>
怨좏삁?? 遺�?뺣㎘, ?λ텇, 李⑸?, 遺덈㈃利? ?꾩뿼, ?ㅼ궗, 蹂�鍮? 援ы넗, ?꾩묠 諛쒓린 吏�?? ?ъ젙 ?μ븷, 誘멸컖 ?뚯떎 ??/a>
<鍮덈룄 遺덈챸>
?ш렐 寃쎌깋, ?�?덉븬, ?ㅼ떊, 諛쒓린???곗옣, 吏�?띿꽦 諛쒓린, ?붾줈 媛먯뿼, ?꾨┰??吏덊솚, 肄?異쒗삁, ?쒕젰 ?�?? ?뚮컻???쒖껌 ??/a>
???몄뿉??移대쭏洹몃씪 怨⑤뱶 蹂듭슜 ???좉꼍 ?곗씠??利앹긽???덉쑝硫?利됱떆 ?섏궗쨌?쎌궗?� ?곷떞?섏꽭??
?ъ슜湲덇린 / 蹂묒슜湲덇린
?ъ슜湲덇린
???쎌쓽 ?깅텇??怨쇰?利앹쓽 蹂묐젰?댁엳???섏옄
吏덉궛???먮뒗 ?쇱궛??吏덉냼 (NO) 怨듭뿬 ??(?덊듃濡?湲�由ъ꽭由? ?꾩쭏???꾨? 吏덉궛 ?댁냼 ?뚮Ⅴ 鍮꾨뱶 ??瑜??ъ뿬以묒씤 ?섏옄
?ы삁 愿�怨??μ븷瑜?媛뽯뒗 ???깊뻾?꾧? 遺�?곸젅?섎떎怨??앷컖?섎뒗 ?섏옄
以묒쬆??媛꾧린???μ븷媛� ?덈뒗 ?섏옄
?�?덉븬 ?섏옄 (?덉븬 <90/50 mmHg) ?먮뒗 移섎즺???섑븳 愿�由ш? ?대（?댁?吏� ?딅뒗 怨좏삁???섏옄 (?댁떇 ?섏텞湲??덉븬> 170 mmHg ?먮뒗 ?댁떇 ?댁셿湲??덉븬> 100 mmHg)
?뚭꼍??쨌 ?뚯텧?덇낵 ?ш렐 寃쎌깋??蹂묐젰??理쒓렐 6 媛쒖썡 ?대궡???섏옄
留앸쭑 ?됱냼 蹂�?깆쬆 ?섏옄
?꾨??ㅻ떎濡??쇱궛??(寃쎄뎄??瑜??ъ뿬以묒씤 ?섏옄
媛�?⑹꽦 援ъ븘?먯궛 ?쒖퓼?쇱젣 (sGC) ?먭레??(由ъ삤?쒓뎄?꾪넗)瑜??ъ뿬以묒씤 ?섏옄
蹂묒슜 湲덇린
吏덉궛??諛?NO 怨듭뿬??(?덊듃濡?湲�由ъ꽭由? ?꾩쭏???꾨? 吏덉궛 ?댁냼 ?뚮Ⅴ 鍮꾨뱶 ??
?꾨??ㅻ떎濡??쇱궛??(?덉뭅濡???
由ъ삤?쒓뎄?꾪듃 (Riociguat, ?꾨??뚯뒪 Adempas)
?⑸쾿 諛??⑸웾
?듭긽 ?깆씤 1 ??1 ???ㅻ뜲?섑븘濡쒖꽌 25mg (0.25 ?? ~ 50mg (0.5 ?????깊뻾????1?쒓컙 ?꾩뿉 蹂듭슜?⑸땲??
怨좊졊??(65 ???댁긽) 媛??μ븷媛�?덈뒗 ?щ엺怨?以묒쬆???좎옣??(Ccr <30mL/min)?댁엳??遺꾩? 遺�?묒슜???쇱쑝???곕젮媛� ?덉쑝誘�濡?25mg (0.25 ???먯꽌 蹂듭슜???쒖옉?섎룄濡앺븯怨?諛붾엻?덈떎.
1 ??蹂듭슜?� 1 ?뚮줈 ?섍퀬, 蹂듭슜 媛꾧꺽?� 24 ?쒓컙 ?댁긽?쇰줈 ?섏떗?쒖삤.
誘멸뎅?대굹 ?좊읇?먯꽌?? 利앹긽???곕씪 理쒕? 100mg源뚯? 蹂듭슜 媛�?ν빀?덈떎.
??Ccr : ?щ젅?꾪떚???대━?대윴??(?좎옣???좎껜???명룓臾쇱쓣 諛곗꽕?섎뒗 ?λ젰 吏�??
理쒕??쒖쓽 ?④낵瑜??산린 ?꾪빐
鍮꾩븘洹몃씪 蹂듭슜 ??諛쒓린 ?좊컻?④낵媛� 理쒕?媛� ?섎뒗 寃껋씠 0.8 ~ 0.9 ?쒓컙 ?꾩씠誘�濡??깊뻾????1 ?쒓컙 ?꾩뿉 蹂듭슜?섎룄濡??섏떗?쒖삤.
?앹궗?� ?④퍡 蹂듭슜?섎㈃ 怨듬났??蹂듭슜?섎뒗 寃쎌슦??鍮꾪빐 諛쒓린 ?좊컻 ?④낵媛� 吏�???????덉뒿?덈떎. 諛섎뱶??怨듬났??蹂듭슜?섎룄濡??섏떗?쒖삤.
?④퍡 ?쒕꼫吏� ?④낵媛�?덈뒗 ?쎌젣
議곕（ 諛⑹?: 由щ룄移댁씤 ?⑥쑀 ?ㅽ봽?덉씠, ?ㅽ룺?명떞 ???꾨┫由ъ? ?? ??ED 移섎즺?쒖? 蹂묒슜 ???섏궗 ?곷떞 ?꾩닔
- 移대쭏洹몃씪 ??/a>
遺�?묒슜
-鍮덈룄蹂?二쇱슂 遺�?묒슜 諛??꾩긽 寃�?ъ튂 ?댁긽
<1 % ?댁긽>
?덇? ?뺤옣 (?띿“, ?띿“), ?먰넻
<0.1 ~ 1 % 誘몃쭔>
媛�?댄넻利? 媛�?대몢洹쇨굅由? 留λ컯??鍮⑤씪吏? ?꾧린利? 議몃┝, ?쇰?, AST (GOT) 利앷?, 援ъ뿭吏? ?꾩옣 ?μ븷, 援ш컝, ?뚰솕 遺덈웾, 蹂듯넻, 鍮꾩뿼, 愿�?덊넻, 洹쇱쑁?? 諛쒖쭊, ??異⑺삁, 寃곕쭑?? 愿묒떆利? ?쒓컖 ?μ븷, CK (CPK) 利앷?, ?듭쬆, 紐몄쓽 ?닿린
<0.1 %>
怨좏삁?? 遺�?뺣㎘, ?λ텇, 李⑸?, 遺덈㈃利? ?꾩뿼, ?ㅼ궗, 蹂�鍮? 援ы넗, ?꾩묠 諛쒓린 吏�?? ?ъ젙 ?μ븷, 誘멸컖 ?뚯떎 ??/a>
<鍮덈룄 遺덈챸>
?ш렐 寃쎌깋, ?�?덉븬, ?ㅼ떊, 諛쒓린???곗옣, 吏�?띿꽦 諛쒓린, ?붾줈 媛먯뿼, ?꾨┰??吏덊솚, 肄?異쒗삁, ?쒕젰 ?�?? ?뚮컻???쒖껌 ??/a>
???몄뿉??蹂듭슜 萸붽? ?좉꼍 ?곗씠??利앹긽???덉쑝硫?利됱떆 ?섏궗 쨌 ?쎌궗?� ?곷떞?섎룄濡앺븯??떆??
?ъ슜湲덇린/蹂묒슜湲덇린
?ъ슜湲덇린
???쎌쓽 ?깅텇??怨쇰?利앹쓽 蹂묐젰?댁엳???섏옄
吏덉궛???먮뒗 ?쇱궛?붿쭏??(NO) 怨듭뿬??(?덊듃濡?湲�由ъ꽭由? ?꾩쭏???꾨? 吏덉궛 ?댁냼 ?뚮Ⅴ 鍮꾨뱶 ??瑜??ъ뿬以묒씤 ?섏옄
?ы삁 愿�怨??μ븷瑜?媛뽯뒗 ???깊뻾?꾧? 遺�?곸젅?섎떎怨??앷컖?섎뒗 ?섏옄
以묒쬆??媛?湲곕뒫 ?μ븷媛� ?덈뒗 ?섏옄
?�?덉븬 ?섏옄 (?덉븬 <90/50 mmHg) ?먮뒗 移섎즺???섑븳 愿�由ш? ?대（?댁?吏� ?딅뒗 怨좏삁???섏옄 (?댁떇 ?섏텞湲??덉븬> 170 mmHg ?먮뒗 ?댁떇 ?댁셿湲??덉븬> 100 mmHg)
?뚭꼍??쨌 ?뚯텧?덇낵 ?ш렐 寃쎌깋??蹂묐젰??理쒓렐 6 媛쒖썡 ?대궡???섏옄
留앸쭑 ?됱냼 蹂�?깆쬆 ?섏옄
?꾨??ㅻ떎濡??쇱궛??(寃쎄뎄??瑜??ъ뿬以묒씤 ?섏옄
媛�?⑹꽦 援ъ븘?먯궛 ?쒖퓼?쇱젣 (sGC) ?먭레??(由ъ삤?쒓뎄?꾪넗)瑜??ъ뿬以묒씤 ?섏옄
蹂묒슜 湲덇린
吏덉궛 ??諛?NO 怨듭뿬 ??(?덊듃濡?湲�由ъ꽭由? ?꾩쭏???꾨? 吏덉궛 ?댁냼 ?뚮Ⅴ 鍮꾨뱶 ??
?꾨??ㅻ떎濡??쇱궛??(?덉뭅濡???
由ъ삤?쒓뎄?꾪듃 (Riociguat, ?꾨??뚯뒪 Adempas)
?⑸쾿 諛??⑸웾
?듭긽 ?깆씤 1??1???ㅻ뜲?섑븘濡쒖꽌 25mg (1/4 ?? ~ 50mg (1/2 ?????깊뻾????1?쒓컙 ?꾩뿉 蹂듭슜?⑸땲??
?먰븯??留쏆쓽 移대쭏洹몃씪 援ш컯 ?ㅻ━瑜?蹂듭슜?섏꽭??
?댁쇅?먯꽌??100mg(1?? 1??蹂듭슜 ?⑸쾿???덉쑝?? 泥섏쓬?먮뒗 50mg ?댄븯 ?�?⑸웾遺�???쒖옉?섎뒗 寃껋씠 ?덉쟾?⑸땲??
泥댁쭏???곕씪 100mg??泥섏쓬遺�??蹂듭슜?섎㈃ 遺�?묒슜 ?꾪뿕???믪븘吏????덉뒿?덈떎.
泥섏쓬?먮뒗 ?�?⑸웾遺�??蹂듭슜???쒖옉?섎룄濡??섏떗?쒖삤.
怨꾩냽 蹂듭슜 ??寃쎌슦 24 ?쒓컙 ?댁긽 媛꾧꺽???먮뒗 ?덈룄濡앺븯??떆??
理쒕??쒖쓽 ?④낵瑜??산린 ?꾪빐
李멸퀬濡? ?좏슚 ?깅텇 ?ㅻ뜲?섑븘?� ?앺썑??蹂듭슜 ??踰꾨━硫?諛쒓린 ?좊컻 ?묒슜???쏀빐??踰꾨┛?ㅻ뒗 寃껋엯?덈떎.
蹂듭슜 ???뚮뒗 ?앺썑媛� ?꾨땲??怨듬났??蹂듭슜?섎뒗 寃껋씠 醫뗭뒿?덈떎.
?④퍡 ?쒕꼫吏� ?④낵媛�?덈뒗 ?쎌젣
移대쭏洹몃씪 ???명듃??諛쒓린遺�??移섎즺?쒖씠硫? ?뺣젰?쒕굹 理쒖쓬??議곕（ ?덈갑?쎌씠 ?꾨떃?덈떎. ?깊뻾?꾩뿉?쒖쓽 ?깆쟻 ?깅뒫???μ긽?섍퀬?먰븳?ㅻ㈃ ?ㅼ쓬怨?媛숈? ?섏빟?덇낵??蹂묒슜??沅뚯옣?낅땲??
議곕（ 諛⑹?: 由щ룄移댁씤 ?⑥쑀 ?ㅽ봽?덉씠, ?ㅽ룺?명떞 ???꾨┫由ъ? ?? ??蹂묒슜 ???섏궗 ?곷떞 ?꾩닔
?뺤븸???뫢룹쭏 媛쒖꽑: 留덉뭅, ?꾩뿰 ???곸뼇 蹂댁“??/a>
?깆슃쨌?쒕젰: ?뚯뒪?좎뒪?뚮줎 蹂댁땐??????諛섎뱶???섏궗 泥섎갑쨌?곷떞 ???ъ슜
?댁긽?낅땲??
????紐⑤몢 ?숈씪???쎌꽦遺꾩뿉 ?뺥깭留??ㅻⅨ 留뚰겮, 蹂듭슜諛⑸쾿怨?遺�?묒슜?� ?숈씪??寃껋쓣 ?뺤씤?????덉뒿?덈떎.
移대쭏洹몃씪 ?뺤젣?� ?ㅻ━???숈씪???ㅻ뜲?섑븘 ?깅텇?대?濡?蹂듭슜踰빧룸??묒슜쨌二쇱쓽?ы빆??媛숈뒿?덈떎. 泥섏쓬?먮뒗 ?�?⑸웾(25~50mg)遺�???쒖옉?섍퀬, 怨듬났 蹂듭슜???≪닔쨌?④낵 硫댁뿉???좊━?⑸땲?? ?앺썑 蹂듭슜 ???쏀슚 諛쒗쁽??吏�?곕맆 ???덉쑝??李멸퀬?섏꽭??
?쎌뼱二쇱뀛??媛먯궗?⑸땲??
??移대쭏洹몃씪 援щℓ?섎윭媛�湲? 移대쭏?명룷
